Immune Checkpoint Inhibitors: New Insights and Current Place in Cancer Therapy

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Target Audience
This activity is intended for oncologists, oncology nurses, oncology nurses, advanced practice nurses, nurse practitioners, registered nurses, oncology pharmacists, and other healthcare providers who are involved in treating patients with metastatic melanoma and advanced non-small-cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) and who are interested in the use of immune checkpoint inhibitors.

Educational Objectives
After completing this activity, the participant should be better able to:

  • Describe the action of immune checkpoints and their effects in blunting antitumor responses
  • Incorporate immune checkpoint inhibitors in the treatment paradigm for patients with advanced melanoma
  • Critically evaluate and incorporate the latest efficacy and safety data on immune checkpoint inhibitors in the treatment of advanced NSCLC
  • Apply emerging data with immune checkpoint inhibitor targeted therapy in HNSCC
  • Discuss emerging molecular and genetic biomarkers that may help in patient selection and guide immune checkpoint inhibitor therapy in patients with metastatic melanoma and advanced NSCLC and HNSCC
  • Evaluate the cost/benefit paradigm of immune checkpoint inhibitors in delivering optimal value-based care
Term of Offering
Release date: October 26, 2016
Expiration date: October 31, 2017

Estimated time to complete activity:1.25 hours
Faculty

Sanjiv S. Agarwala, MD
Professor of Medicine
Temple University School of Medicine
Chief, Medical Oncology & Hematology
St. Luke’s Cancer Center
Bethlehem, PA
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Postgraduate Institute for Medicine and Center of Excellence Media, LLC, do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclosure of Conflicts of Interest
Postgraduate Institute for Medicine (PIM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COIs are thoroughly vetted and resolved according to PIM policy. PIM is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:

Name of Faculty or Presenter Reported Financial Relationship
Sanjiv S. Agarwala, MD Nothing to disclose.

The following PIM planners and managers, Trace Hutchison, PharmD; Samantha Mattiucci, PharmD, CHCP; Judi Smelker-Mitchek, RN, BSN; and Jan Schultz, RN, MSN, CHCP, hereby state that they or their spouse/life partner do not have any financial relationships or relationships to products or devices with any commercial interest related to the content of this activity of any amount during the past 12 months.

Center of Excellence Media, LLC: Susan Berry and Sy Schlager, MD, PhD, hereby state that they or their spouse/life partner do not have any financial relationships or relationships to products or devices with any commercial interest related to the content of this activity of any amount during the past 12 months.
Physician Accreditation Statement
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Postgraduate Institute for Medicine and Center of Excellence Media, LLC. Postgraduate Institute for Medicine is accredited by the ACCME to provide continuing medical education for physicians.
Physician Credit Designation
Postgraduate Institute for Medicine designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Pharmacist Continuing Education Accreditation Statement Postgraduate Institute for Medicine is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
Credit Designation
Postgraduate Institute for Medicine designates this continuing education activity for 1.2 contact hour(s) (0.12 CEUs) of the Accreditation Council for Pharmacy Education. (Universal Activity Number – 0809-999-16-493-H01-P).
Continuing Nursing Education
The Postgraduate Institute for Medicine is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation. The educational activity for 1.2 contact hours is provided by Postgraduate Institute for Medicine. Designated for 0.8 contact hours of pharmacotherapy credit for advance practice registered nurses.
Type of Activity: Application
Instructions for Credit
There is no fee for this activity. To receive credit after reading this CME/CE activity in its entirety, participants must complete the posttest and evaluation. The posttest and evaluation can be completed online at http://ce.lynxcme.com/COE442. Upon completion of the evaluation and scoring 75% or better on the posttest, you will immediately receive your certificate online. If you do not achieve a score of 75% or better on the posttest, you will be asked to take it again. Please retain a copy of the certificate for your records.

For Pharmacists: Upon successfully completing the posttest with a score of 75% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.

If you have any questions regarding the CME/CE certification for this activity, please contact Postgraduate Institute for Medicine at: information@pimed.com or 303-799-1930.
Disclaimer
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Media: Internet
System Requirements
Windows 7 or higher or Mac OS X 10.6 or higher
Internet Explorer v9.0 or higher
Latest version of Google Chrome, Firefox, or Safari
Adobe Flash Player v10.0 or higher.
Adobe Acrobat Reader v7.0 or higher*

*Required to view printable (PDF) version of the lesson.
Provider Statement
This activity is jointly provided by Postgraduate Institute for Medicine and Center of Excellence Media, LLC.
Center of Excellence Media

This activity is supported by an independent educational grant from Merck.

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